Active Pharmaceutical Ingredients CAS 9067-32-7 Sodium Hyaluronate
|FOB Price:||US $1 / g|
|Min. Order:||10 g|
|Min. Order||FOB Price|
|10 g||US $1/ g|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 9067-32-7
- Customized: Customized
- Suitable for: Elderly
- Purity: >99%
- CAS: 9067-32-7
- Shipping: Safe
- Transport Package: as You Requiry
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP
- State: Solid
- Name: Sodium Hyaluronate
- Sample: Free
- Trademark: saichuang
- Specification: 99%
- HS Code: 3001200090
|Product name:||Sodium hyaluronate|
|Other Name:||cockscomb;Healon;Hyaluronesodium;hyaluronic;Si-4402;Sl-1010;Sph;SODIUM HYALURONATE (STREPTOCOCCUS);|
|Leading time||within 24 hours upon receipt of payment|
|Delivery||Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS|
|Package||Discreet and Hidden package according to specific requirement|
|Certification||SGS, ISO 9001, KOSHER|
|Payment Terms||Western Union, Money Gram , T/T, Bitcoin|
|Minimum Order Quantity||10g|
|Usage||Cosmetic use; antifungal agent; prevents thromboembolic complications; aldosterone antagonist used as an adjunct in the management of chronic heart failure|
Description of Active Pharmaceutical Ingredients Sodium hyaluronate:
1. Sodium hyaluronate is also called Hyaluronic acid sodium, is physiological active substances, which is widely exists in the human body. It is high molecular weignt straight-chain mucopolysaccharides, which is composed of glucuronic acid and acetyl amino hexose polymerizatio. its molecular weight is 1 million.
2. In water, It can form a thick viscoelastic solution, has the physiological ph and ionic strength. The molecular configuration is variable, so also can be done with a fine needle. Sodium hyaluronate won't produce inflammatory substances , called Healon. The 10 mg dissolved in 1 ml saline solution, its thick viscosity is 200000 times higher than aqueous humor or saline water. Healon protein content is less than 0.5%, and a sterile solution with high purity.
Medical Usage of Active Pharmaceutical Ingredients Sodium hyaluronate :
It is used to treat knee pain in patients with osteoarthritis who have not received relief from other treatments. It is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint. Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee, increasing the viscosity of the synovial fluid, which helps lubricate, cushion and reduce pain in the joint.
It is generally used as a last resort before surgery and provides symptomatic relief, by recovering the viscoelasticity of the articular fluid, and by stimulating new production from synovial fluid. Use of sodium hyaluronate may reduce the need for joint replacement. Injections appear to increase in effectiveness over the course of four weeks, reaching a peak at eight weeks and retaining some effectiveness at six months, with greater benefit for osteoarthritis than oral analgesics. It may also be effective when used with ankle join.
Intraocular viscoelastic injection
It is used as an aid in ophthalmic surgery acting as aqueous and vitreous humor, e.g. in cataract extraction(intra- and extracapsular), intraocular lens implantation, corneal transplant, glaucoma filtration, and retina attachment surgery and in the treatment of dry eyes. In surgical procedures in the anterior segment of eyeball, instillation of sodium hyaluronate its viscoelasticity enables maintenance of a deep chamber during surgical manipulation since the solution does not flow out of the open anterior chamber, allowing for efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues.
Its viscoelasticity also helps to push back the vitreous face and prevent formation of a postoperative flat chamber. In posterior segment surgery, sodium hyaluronate serves as a surgical aid to gently separate, maneuver, and hold tissues. It creates a clear field of vision, facilitating intra-operative and post-operative inspection of the retina and photocoagulation.
Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis.
Skin injections in plastic surgery
Sodium hyaluronate is injected to reduce wrinkles on the face. As of 2017, the FDA had approved 13 hyaluronate preparations as so called dermal fillers. They are also used as a filler of lips or in other parts of the body, though not FDA approved. The filling effect is temporary and lasts for about six months or longer in most people.
Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier. Its effects on skin depend on the hyaluronate formulation and skin health: In barrier-deficient skin it restricted the delivery of biomacromolecules to the stratum corneum and viable epidermis. In normal skin, low-molecular weight hyaluronate (5 kDa) enhanced penetration into the epidermis.
Transepidermal water loss increased by 55.5% with low-molecular weight , and was reduced by 28% with crosslinked resilient , and by 16% with HMW. The addition to skin creams became popular in the second millenium. Its efficacy against wrinkles has not been tested in clinical trials.
After instillation into the lung, higher molecular weight hyaluronate appears to persist longer in the lung but if > 215 kD there was poor lung penetration and mucociliary clearance. Hyaluronate could allow access to lymph nodes draining the pulmonary bed.
Clinical Application of Active Pharmaceutical Ingredients Sodium hyaluronate :
1.Used in the surgeries such as intraocular lens, cataracts, glaucoma, corneal transplantation and retinal detachment;
2.Used in dry eye syndrome.
3.Widely used in high-end cosmetics industry, used in dry eye syndrome.
4.Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
5.It prevents thromboembolic complications.
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