High Purity Antibiotics Powder CAS 104987-11-3 Tacrolimus
|FOB Price:||US $1 / g|
|Min. Order:||10 g|
|Min. Order||FOB Price|
|10 g||US $1/ g|
|Payment Terms:||T/T, Western Union, Money Gram|
- Model NO.: 104987-11-3
- Customized: Customized
- Suitable for: Elderly
- Purity: >99%
- CAS: 104987-11-3
- Shipping: Safe
- Transport Package: as You Requiry
- Origin: China
- Powder: Yes
- Certification: ISO 9001, USP
- State: Solid
- Name: Tacrolimus
- Sample: Free
- Trademark: saichuang
- Specification: 99%
- HS Code: 3001200090
|Leading time||within 24 hours upon receipt of payment|
|Delivery||Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS|
|Package||Discreet and Hidden package according to specific requirement|
|Appearance||White crystal powder|
|Certification||SGS, ISO 9001, KOSHER|
|Payment Terms||Western Union, Money Gram , T/T, Bitcoin|
|Minimum Order Quantity||10g|
Description of Active Pharmaceutical Ingredients Tacrolimus :
1. Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body's learned (or adaptive) immune response.
2. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura's disease, and the skin condition vitiligo.
Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
3. Chemically it is a 23-membered macrolide lactone that was first discovered in 1987 from the fermentation broth of a Japanese soil sample that contained the bacterium Streptomyces tsukubaensis.
Medical Usage of Active Pharmaceutical Ingredients Tacrolimus:
Immunosuppression following transplantation:
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long-term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and IL-2 receptor inhibitors such as basiliximab. Dosages are titrated to target blood levels.
In recent years, tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (UC), a form of inflammatory bowel disease. Although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of outbreaks of UC.
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way tosteroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.
Technical Testing Sheet of Active Pharmaceutical Ingredients Tacrolimus:
|Identification (IR)||Should match with working standard||Confirms|
|Water by KF||Not more than 0.5%||0.14%|
|Loss on drying||Not more than 0.5%||0.17%|
|Residue on ignition||Not more than 0.2%||0.05%|
|Heavy Metals||Not more than 20ppm||Confirms|
|Single maximum impurity||Not more than 0.5%||0.34%|
|Total impurities||Not more than 1.0%||0.66%|
|Assay by HPLC||98.0% -102.0%||101.0%|
|Conclusion||conforms with USP 32 Standard|
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