High Quality Bupivacaine for Local Anaesthesia 2180-92-9
|FOB Price:||US $1 / gram|
|Min. Order:||10 gram|
|Min. Order||FOB Price|
|10 gram||US $1/ gram|
|Production Capacity:||1 Metric Ton/Month, 5000kg/Month|
|Payment Terms:||L/C, T/T, D/P, Western Union, Paypal, Money Gram|
- Model NO.: 2180-92-9
- Customized: Powder
- Suitable for: Elderly, Children, Adult
- Purity: >98%
- CAS: 2180-92-9
- Shipping: Safe
- MW: 288.34
- Transport Package: 25kg/Drum or as Per Your Requirements
- Origin: Hubei
- Powder: Yes
- Certification: GMP, ISO 9001
- State: Powder
- Name: Bupivacaine
- Sample: Free
- Package: 25kg/Drum
- Trademark: Nanjian
- Specification: Appearance: white crystalline powder
- HS Code: 30013006
Synonyms: MARCAINE; BUPIVACAINE; BUPIVACAINE BASE; (.+/-.)-1-Butyl-2',6'-pipecoloxylidide; 1-Butyl-2-(2,6-xylycarbamoyl)piperidine; 1-Butyl-2',6'-pipecoloxylidide; 1-butyl-2',6'-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamid
Bupivacaine is only found in individuals that have used or taken this drug. It is a widely used local anesthetic agent. Bupivacaine blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.
• Infiltration anaesthesia.
• Peripheral and sympathetic nerve block.
• Dental anaesthesia.
• Spinal anaesthesia.
• Epidural and caudal anaesthesia (these techniques produce prolonged regional anaesthesia, and should be attempted only by experienced specialist anaesthetists).
Dosage and administration
The aim is to administer the smallest effective dose. This varies with the procedure adopted, the degree of anaesthesia required, the rate of absorption from the injection site and the size and responsive-ness of the patient. Higher initial blood levels are attained with more concentrated solutions.
The maximum cumulative safe dose for adults and children of a 0.25% solution of bupivacaine is 1.5 mg/kg. Smaller dosages should be administered to debilitated, elderly, epileptic and acutely ill patients.
Bupivacaine is generally not recommended for children aged less than 12 years since there is insufficient information on the effects of its use in this age group.
Solutions containing preservatives should not be used for spinal, epidural or caudal anaesthesia.
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