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Supplier Homepage Product Pharmaceutical Intermediate High Purity Empagliflozin for Antidiabetic CAS 864070-44-0

High Purity Empagliflozin for Antidiabetic CAS 864070-44-0

FOB Price: US $1 / g
Min. Order: 1 g
Min. Order FOB Price
1 g US $1/ g
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Port: Hong Kong, Hong Kong
Production Capacity: 1000kg
Payment Terms: T/T, Western Union, Money Gram, bitcoin

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Basic Info
  • Model NO.: 864070-44-0
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 864070-44-0
  • Sample: Free
  • Transport Package: Foil Bag
  • Origin: Hongkong
  • Powder: Yes
  • Certification: ISO 9001, USP, BP
  • State: Solid
  • Name: Empagliflozin
  • Shipping: FedEx, DHL, EMS, TNT, HK EMS, Eub, Etk
  • Trademark: zsyh
  • Specification: 99%
  • HS Code: 134657687
Product Description
Quack Detail for EMpagliflozin
 
Product Name:EMpagliflozin
Synonyms:EMpagliflozin;BI-10773;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol;EMpagliflozin/ BI-10773;EMPAGLIFLBZIN;(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-6-(hydroxyMethyl)-tetrahydro-2H-pyran-3,4,5-triol;D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]M ethyl]phenyl]-, (1S)-;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol Empagliflozin BI 10773
CAS:864070-44-0
MF:C23H27ClO7
MW:450.90928
Product Categories:API;Inhibitors
Mol File:864070-44-0.mol
UsageEmpagliflozin is a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.

Empagliflozin (trade name Jardiance) is really a drug from the gliflozin class, approved for that treatments for diabetes type 2 in adults in 2014. It turned out put together by Boehringer Ingelheim and Eli Lilly and Company.
Empagliflozin is an inhibitor with the sodium glucose co-transporter-2 (SGLT-2), and results in sugar in the blood being excreted by the kidneys and eliminated in urine.

About the Empagliflozin

Empagliflozin is really a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM .
Sodium glucose cotransporter-2 (SGLT-2) is part of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney .

Empagliflozin is a potent SGLT-2 inhibitor and it has a high amount of selectivity over SGLT-1, 4, 5 and 6 than other reported SGLT-2 inhibitors. When tested using a panel of human cell lines over-expressed SGLT-1, 2, 4, 5 and 6,

Empagliflozin treatment competitively bind to SGLT-2 over glucose at low dose . In human proximal tublular cell (PTC) cell line HK2 cells, Empagliflozin answer to 72 h inhibits the expression of SGLT-2 which reversed high glucose induced TLR4 expression, NF-κB binding, IL-6 secretion, AP-1 binding and CIV expression .

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High Purity Empagliflozin for Antidiabetic CAS 864070-44-0
High Purity Empagliflozin for Antidiabetic CAS 864070-44-0
High Purity Empagliflozin for Antidiabetic CAS 864070-44-0
 
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