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Cabozantinib Malate, Buy Cabozantinib Malate, CAS 1140909-48-3 manufacturer / supplier in China, offering Buy Top Purity Cabozantinib Malate, Injection / Oral Body Building Test Enan Powder with Safe Shipping, Top Quality 99% Reserpine CAS: 50-55-5 and so on.

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Buy Top Purity Cabozantinib Malate

FOB Price: US $1 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1/ g
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Port: Shenzhen, China
Production Capacity: 5000kg/Month
Payment Terms: T/T, Western Union, Paypal, Money Gram, Bitcoin

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Basic Info
  • Model NO.: CAS 1140909-48-3
  • Customized: Non-Customized
  • Suitable for: Children, Adult
  • Purity: >99%
  • CAS: 1140909-48-3
  • Sample: Free
  • Market: Global
  • Transport Package: Well Disguised Package; Foil Bag
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Product Name: Cabozantinib Malate
  • Delivery: Safe
  • Shipping: FedEx, DHL, EMS, TNT, HK EMS, Eub, Etk
  • Trademark: Pharmlab
  • Specification: 25kg/drum; 1kg/foil bag
Product Description
English name: Cabozantinib Malate
Synonyms: (2S) -2-Hydroxybutanedioic acid compd. With N- [4 - [(6,7-dimethoxy-4-quinolinyl) oxy] phenyl] -N '- (4-fluorophenyl) -1,1-cyclopropanedicarboxamide (1: 1); Cabozantinib (S) -malate; Cabozantinib L-Malate Salt
CAS Number: 1140909-48-3
Molecular formula: C32H30FN3O10
Molecular weight: 635.5931032
EINECS number:
Related categories: protein tyrosine kinase; small molecule inhibitors; Inhibitors; small molecule inhibitors, natural products; anti-thyroid medullary carcinoma; pharmaceutical raw materials;
Mol file: 1140909-48-3.mol

Description of Cabozantinib Malate 

Cabozantinib malate is a potent inhibitor of MET andVEGF receptor2 with IC50 values of 1.3nM and 0.035nM.
Cabozantinib is a pan-tyrosine kinase inhibitor and is developed as an oral treatment of various cancers including MTC, GBM, NSCLC, pancreatic carcinoma, breast and colon cancer. The targets of cabozantinib are MET, VEGFR-2, RET, FLT3, KIT, AXL as well as TEK. In cellular assays, cabozantinib inhibits the phosphorylation of MET, VEGFR2, KIT, FLT3 and AXL .
Cabozantinib Malate Pharmacological Effects

 The drug is mainly targeted at MET and VEGFR2 tyrosine kinases that associated with the growth and proliferation of prostate cancer, inhibiting tumor metastasis and angiogenesis. Cabozantinib S-MALATE , the malate of Cabozantinib, is an effective VEGFR2 inhibitor, and IC50 is 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2 and AXL, and IC50 is 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM respectively.

 And advanced renal cell carcinoma in people who have received prior anti-angiogenic therapy. It is currently undergoing clinical trials for the treatment of prostate, bladder, ovarian, brain, melanoma, breast, non-small cell lung, pancreatic, and hepatocellular cancers.

Cabozantinib (S)-malate salt is a white to off-white solid that is practically insoluble in aqueous media.

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