Hubei, China
Business Type:
Manufacturer/Factory
Business Range:
Agriculture & Food, Chemicals, Health & Medicine, Sporting Goods & Recreation
Management System Certification:
ISO 9001, GMP
Export Year:
2016-10-09
Main Markets:
North America, South America, Eastern Europe, Southeast Asia, Africa, Oceania, Mid East, ...
OEM/ODM Service
Sample Available

Cilostazol, Cilostazol Powders, Cilostazol Online manufacturer / supplier in China, offering Antithrombotic Pharmaceutical Raw Materials Cilostazol CAS 73963-72-1, China Recommend Antiglaucoma Agent CAS 155206-00-1 Bimatoprost, China Recommend Male Hair Loss API CAS 866460-33-5 Setipiprant and so on.

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Antithrombotic Pharmaceutical Raw Materials Cilostazol CAS 73963-72-1

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Min. Order / Reference FOB Price
10 g US $1/ g
Port: Shanghai, China
Production Capacity: 2000kg/M
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Powder: Yes
Customized: Non-Customized
Certification: GMP, ISO 9001, USP, BP
Suitable for: Elderly, Adult
State: Solid
Purity: >99%

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Basic Info

Model NO.: 73963-72-1
CAS: 73963-72-1
Assay: 99%
Alias: Cilostazol
Appearance: White Powders
Trademark: WHSO
Transport Package: 1kg/Aluminum Foil Bag
Specification: 99%
Origin: China
HS Code: 3001200020

Product Description

Antithrombotic Pharmaceutical Raw Materials Cilostazol CAS 73963-72-1


China Recommend Steroid Powders/Injection Steroid liquid/Peptides/Sarms/Local anesthetics/Nootropics/Antidepressant/Health Care Supplement......


Product Name: Cilostazol
Synonyms: 6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY]-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1h)-quinolinone additional name: 6-[4-(1-cyclohexyl-5-tetrazolyl)butoxy]-1,2,3,4- tetrahydro-2-oxoquinolinone;CILASTAZOL;CILOSTAZOL;CILOSTAZOLE;RETAL;OPC 13013;OPC 21
CAS: 73963-72-1
MF: C20H27N5O2
MW: 369.46
Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;inhibitor;Cardiovascular APIs
Melting point  159-160°C
Storage temp.  Store at RT
Chemical Properties : White crystalline powders
Usage : antibacterial; LD50(iv) 280mg/kg(mouse) 
Usage : A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo .


 
Pharmacological effects

Cilostazol is commonly used clinically anti-platelet and anti-clotting drugs. It belongs to a phosphodiesterase inhibitor and can inhibit the activity of phosphodiesterase of platelet and smooth muscle cells, leading to increase of the cAMP concentration in platelets and vascular smooth muscle. It can significantly inhibit the platelet aggregation induced by various kinds of aggregation inducers, and can cause the dissociation of the aggregates. Its major metabolite, epoxide has a three to four fold activity of the prototype drug. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate. Artery injection of this product can increase the blood flow rate with the strongest effect on the peripheral blood vessels but the weakest effect on the cerebral blood vessels. 

This product is rapidly absorbed in the intestine after oral administration with the Tmax being 3h, PPB being about 95%. Consecutive administration of four days by twice per day caused no increase in the plasma concentration accumulation. It has good tissue distribution with especially high level in the stomach, liver and kidney. At 72h after administration, 42.75% of the administered drug is excreted via urine and 61.7% is subject to fecal excretion. After 48 hour of administration, bile excretion rate is 31.7%. T1 / 2α is 2.2h and T1 / 2β is 18h.  


 
Cilostazol Clinical Application

It can be used to alleviate the ischemic symptom such as ulcers, limb pain, cold sensation and intermittent claudication caused by chronic arterial occlusive disease. It can also be applied to the adjuvant treatment of atherosclerosis, arteritis, thromboangiitis obliterans, diabetes-induced ischemia of extremity and takayasu arteritis. Cilostazol also be used as a complementary therapy after surgical treatment to help alleviate the symptoms, improve the circulation and inhibiting thrombosis in transplanted blood vessel . 

 
Cilostazol Uses 

It can significantly inhibit the platelet aggregation caused by various inducers and aggregates and can dissociate the aggregates without causing secondary aggregation. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate. It can also be used for treating ischemic diseases such as chronic arterial occlusive ulcer, pain and coldness . 


 
Our advantages

1. Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years,our products have exported to USA,Greece, Spain, UK, Australia and other countries, and we have got very good feedback from our customers, we had established a long friendly relations

2. Great quality, purity and favorable.
Good quality is one of our biggest secret to success; you can get the best quality and service from us.

3. Safest and fastest delivery.
We have adequate stock so that we can deliver the products within 24 hours as soon as receiving the payment. Fast and discreet shipment will be arranged to pass Customs.

4. Good package.
Unique ways to ship 10g to100kg powders to your destination. We offer melting powder into liquid service and ship the liquid in special bottles.

5. Great after-sales service.
Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.

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