Hubei, China
Business Type:
Manufacturer/Factory
Business Range:
Agriculture & Food, Chemicals, Health & Medicine, Sporting Goods & Recreation
Management System Certification:
ISO 9001, GMP
Export Year:
2016-10-09
Main Markets:
North America, South America, Eastern Europe, Southeast Asia, Africa, Oceania, Mid East, ...
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Rebamipide, Rebamipide Powders, Rebamipide Online manufacturer / supplier in China, offering Gastroduodenal Ulcers Medication Rebamipide for Digestive System CAS 90098-04-7, Tanning Injectionable Peptide Melanotan II / Mt-II/ Mt2, Polypeptide Hormones Triptorelin Acetate for Peptide Drugs CAS 57773-63-4 and so on.

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Gastroduodenal Ulcers Medication Rebamipide for Digestive System CAS 90098-04-7

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Min. Order / Reference FOB Price
10 g US $1/ g
Port: Hong Kong, Hong Kong
Production Capacity: 50000kg/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Powder: Yes
Customized: Non-Customized
Certification: GMP, ISO 9001, USP, BP
Suitable for: Elderly, Adult
State: Solid
Purity: >99%

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Basic Info

Model NO.: 90098-04-7
CAS: 90098-04-7
Appearance: White Cyrstalline Powder
Express Way: EMS, FedEx, TNT, DHL, Hkems
Alias: Rebamipide
Trademark: WHSO
Transport Package: 25kg/Drum
Specification: 99%
Origin: China
HS Code: 121425246

Product Description

Gastroduodenal Ulcers Medication Rebamipide For Digestive System CAS 90098-04-7


Product Name: Rebamipide 
Synonyms: (+-)-1,2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-4-quinolinepropanoica;(+-)-2-(4-chlorobenzoylamino)-3-(2(1h)-quinolinon-4-yl)propionicacid;1,2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-4-quinolinepropanoicaci(;2-dihydro-alpha-((4-chlorobenzoyl)amino)-2-oxo-(+-)-4-quinolinepropanoicaci;opc12759;opc-12759;Rebamipid;REBAMIPIDE 
CAS: 90098-04-7
MF: C19H15ClN2O4
MW: 370.79
Product Categories: Amino Acid Derivatives;Active Pharmaceutical Ingredients;Antiulcerative;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Melting point : 288-290°C dec.
Storage temp. : -20°C Freezer
Chemical Properties : White Powder
Usage : Shows antiulcer activity in rats
Usage : antiulcer, antioxidant .


New anti-ulcer drug 

Rebamipide, is a new anti-ulcer drug; in 1990, it first entered into market as acute and chronic gastritis drug and anti-gastric ulcer drug in Japan; rebamipide belongs to gastric mucosal protective agent, can increase gastric mucosal blood flow, the synthesis of prostaglandin E2 and the secretion of gastric mucus, promote the expression of epidermal  and its receptor; therefore it is effective in prevention of ulcers and promoting ulcer healing. Studies have shown that it is effective against various experimental gastric ulcers and can promote gastric prostaglandin production, protect the gastric mucosa from the damage of various hazards ulcerogenic factors. It is suitable in the treatment of gastric ulcer, acute gastritis, the chronic gastritis in acute exacerbation stage, and stomach mucosal lesions. Therefore, it has relative high clinical value. 

Rebamipide is a quinolinone derivative that stimulates endogenous PGE2 generation in gastric mucosa, enhancing gastric mucosal defense in a COX-2-dependent manner.

Rebamipide has been shown to inhibit the production of reactive oxygen species and to decrease cytokine release induced by H. pylori infection.

A daily oral dose of 100 mg/kg was found to be protective against the development of pyloric channel ulcers in Mongolian gerbils infected with H. pylori.

In addition to the stomach, rebamipide can also enhance secretion of mucin covering the conjunctiva and cornea, which is important for tear film adhesion.

Rebamipide, a gastroprotective drug, was developed in Japan and was proven to be superior to cetraxate, the former most prescribed drug of the same category, in 1989 in the treatment for gastric ulcers. The initially discovered basic mechanisms of action of rebamipide included its action as a prostaglandin inducer and oxygen free-radical scavenger. In the last 5 years, several basic and clinical studies have been performed for functional dyspepsia, chronic gastritis, NSAID-induced gastrointestinal injuries, gastric ulcer following eradication therapy for Helicobacter pylori, gastric ulcer after endoscopic surgery and ulcerative colitis. In addition, several molecules have been identified as therapeutic targets of rebamipide to explain its pleiotropic pharmacological actions.


Rebamipide Uses 

It is used for treating stomach ulcers .
It is a kind of novel anti-ulcer drugs .  


 
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